Littlefield is a surname. Notable people with the surname include:
Alfred H. Littlefield (1829–1893), Governor of Rhode Island, brother of Daniel
Arthur W. Littlefield, co-founder of publishers Rowman & Littlefield
Catherine Littlefield, ballet dancer
Daniel Littlefield (1822–1891), Central Falls haircloth magnate, Lieutenant governor of Rhode Island, and brother of Alfred
Dave Littlefield, former general manager of the Pittsburgh Pirates
Edmund Wattis Littlefield, CEO of Utah Construction Company
George H. Littlefield, Civil War medal of honor recipient
George W. Littlefield, confederate officer, cattleman, banker and regent of the University of Texas
Henry Littlefield, educator, originator of political interpretations of The Wonderful Wizard of Oz
Jacques Littlefield, founder of the Military Vehicle Technology Foundation (MVTF)
Little Willie Littlefield, blues musician
Milton Smith Littlefield, Union general during United States Civil War