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List of therapeutic monoclonal antibodies

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List of therapeutic monoclonal antibodies

This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies.

The abbreviations in the column Type are as follows:

  • mab: whole monoclonal antibody
  • Fab: fragment, antigen-binding (one arm)
  • F(ab')2: fragment, antigen-binding, including hinge region (both arms)
  • Fab': fragment, antigen-binding, including hinge region (one arm)
  • Variable fragments:
  • scFv: single-chain variable fragment
  • di-scFv: dimeric single-chain variable fragment
  • sdAb: single-domain antibody
  • Bispecific monoclonal antibodies:
  • 3funct: trifunctional antibody
  • BiTE: bi-specific T-cell engager

    • This list includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage.

    References

    List of therapeutic monoclonal antibodies Wikipedia
    (Text) CC BY-SA


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