List of sister cities in Pennsylvania

This is a list of sister states, regions, and cities in the U.S. state of Pennsylvania. Sister cities, known in Europe as town twins, are municipalities (sometimes counties, regions, states and other sub-national entities) that cooperate to foster cultural links. They interact with each other across a broad range of activities, often including education, business, the arts, or health care.

Many Pennsylvania jurisdictions work with foreign cities through Sister Cities International, an organization whose goal is to "Promote peace through mutual respect, understanding, and cooperation."