List of sister cities in North Carolina

This is a list of sister states, regions and cities in the U.S. state of North Carolina. Sister cities, known in Europe as twin towns, are cities which partner with each other to promote human contact and cultural links, although this partnering is not limited to cities and often includes counties, regions, states and other sub-national entities.

Many jurisdictions partner with foreign cities through Sister Cities International, an organization whose goal is to "Promote peace through mutual respect, understanding, and cooperation". Sister cities interact with each other across a broad range of activities, from health care and education to business and the arts.