Lipscomb is a surname. Notable people with the surname include:
David Lipscomb (1831–1917), preacher and founder of Lipscomb UniversityEugene Lipscomb (1931–1963), US football playerGlenard P. Lipscomb (1915–1970), US politician and submarine namesakeGuy Lipscomb (1917–2009), industrialist and watercolorist from Columbia, South CarolinaLila Lipscomb, who appears in the movie Fahrenheit 9/11Mance Lipscomb (1895–1976), US blues musicianOscar Hugh Lipscomb (born 1931), US Roman Catholic ArchbishopOswald Lipscomb (1826–1891), US carpenterSuzannah Lipscomb, English historianWilliam Lipscomb (1919–2011), US inorganic chemist