Lipscomb is a surname. Notable people with the surname include:
David Lipscomb (1831–1917), preacher and founder of Lipscomb University
Eugene Lipscomb (1931–1963), US football player
Glenard P. Lipscomb (1915–1970), US politician and submarine namesake
Guy Lipscomb (1917–2009), industrialist and watercolorist from Columbia, South Carolina
Lila Lipscomb, who appears in the movie Fahrenheit 9/11
Mance Lipscomb (1895–1976), US blues musician
Oscar Hugh Lipscomb (born 1931), US Roman Catholic Archbishop
Oswald Lipscomb (1826–1891), US carpenter
Suzannah Lipscomb, English historian
William Lipscomb (1919–2011), US inorganic chemist
