Lipkin (Hebrew: ליפקין, Russian: Липкин) is a surname. Notable people with the surname include:
Amnon Lipkin-Shahak
Dmitry Lipkin, television writer and playwright
Harry J. Lipkin (1921–2015), Israeli theoretical physicist
Heather Slade-Lipkin, English pianist, harpsichordist and teacher
Malcolm Lipkin
Nikolay Lipkin
Seymour Lipkin (1927–2015), pianist, conductor and teacher
Steven Barry Lipkin (born 1942), American songwriter and record producer
W. Ian Lipkin (born 1952), the John Snow Professor of Epidemiology at the Mailman School of Public Health
Yisrael Lipkin Salanter, Lithuanian Rabbi
Yom Tov Lipman Lipkin, Lithuanian Jewish mathematician, inventor of Peaucellier–Lipkin linkage and son of Yisrael Lipkin Salanter