Linoleate diol synthase

In enzymology, a linoleate diol synthase (EC 1.13.11.44) is an enzyme that catalyzes the chemical reaction

linoleate + O₂ ⇌ (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate

Thus, the two substrates of this enzyme are linoleate and O₂, whereas its product is (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is linoleate:oxygen 7S,8S-oxidoreductase. This enzyme is also called linoleate (8R)-dioxygenase. This enzyme participates in linoleic acid metabolism.