Lineage markers

The lineage markers are characteristic molecules for cell lineages, e.g. cell surface markers, mRNAs, or internal proteins. Certain antibodies can be used to detect or purify cells with these markers by binding to their surface antigens. A standard cocktail of antibodies can be designed to remove or purify mature hematopoietic cells or to detect Cluster of differentiation from a sample. Those antibodies are e.g. targeted to CD2, CD3, CD4, CD5, CD8, NK1.1, B220, TER-119, and Gr-1 in mice and CD3 (T lymphocytes), CD14 (Monocytes), CD16 (NK cells, granulocytes), CD19 (B lymphocytes), CD20 (B lymphocytes), and CD56 (NK cells) in humans.