Lilly is a surname. Notable people with the surname include:
Bob Lilly (b. 1939), American football player and photographer
Colonel Eli Lilly (1839–1898), pharmaceutical chemist, founder of Eli Lilly and Company
Doris Lilly (1922-1991), Writer ("How to Marry a Millionaire," "How to Make Love in Five Languages", etc.)
Evangeline Lilly (b. 1979), Canadian actress* John Lilly (Mozilla) (b. 1971), CEO of the Mozilla Corporation
John Lilly (writer) (circa 1553–1606), English writer
John C. Lilly (1915–2001), American neuroscientist and philosopher
Josiah K. Lilly, Jr. (1893–1966), American industrialist
Josiah K. Lilly, Sr. (1861–1948), American industrialist
Ken Lilly (b. 1959), Australian cricketer
Kenneth Norman Lilly (1929–1996), British artist
Kevin Lilly (born 1963), American football player
Kristine Lilly (b. 1971), American soccer player
Mike Lilly, American comic book artist
Ted Lilly (b. 1976), left-handed pitcher in Major League Baseball
Thomas Jefferson Lilly (1878–1956), American politician
William Lilly (1602–1681), English astrologer