Levene is a surname. Notable people with the surname include:
Allan Levene, (born 1949 or 1950), British American information technology specialist and political candidateGeorge Levene (1885–1930), American football player and coach at the college levelGus Levene (1911-1979), American composer, arranger, orchestrator, guitaristGustavo Gabriel Levene (1905–1987), Argentinian historian and writerHarry Levene, English boxing promoter, associated with Terry LawlessJohn Levene (born 1941), English film and television actorKeith Levene (born 1957), English guitarist and songwriterPeter Levene (born 1941), English businessman and noblemanPhoebus Levene (1869–1940), biochemist who identified the components of DNARebecca Levene, British authorSam Levene (1905–1980), American stage and film actor