Leukotriene E4 20 monooxygenase

In enzymology, a leukotriene-E4 20-monooxygenase (EC 1.14.13.34) is an enzyme that catalyzes the chemical reaction

(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14- tetraenoate + NADPH + H⁺ + O₂ ⇌ 20-hydroxyleukotriene E₄ + NADP⁺ + H₂O

The 5 substrates of this enzyme are (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-, tetraenoate, NADPH, H⁺, and O₂, whereas its 3 products are 20-hydroxyleukotriene E4, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-te traenoate,NADPH:oxygen oxidoreductase (20-hydroxylating). This enzyme is also called leukotriene-E4 omega-hydroxylase. This enzyme participates in arachidonic acid metabolism.