Leukoencephalopathy with neuroaxonal spheroids

Leukoencephalopathy with neuroaxonal spheroids is a special kind of leukoencephalopathy. It is a cause of severe and subacute dementia. It is inherited, following an autosomal dominant pattern.

It usually presents in childhood but it can also have an adult onset. In this case, it can present MRIs that mimic those of progressive multiple sclerosis.