Lesieur is a surname, and may refer to:
Art Lesieur (1907–1967), American ice hockey player
Émile Lesieur (1885–1985), French rugby player
Eugène Lesieur (1890–1975), French wrestler
Jean-Pierre Lesieur (born 1935), French poet
Georges Lesieur (1848–1931), French businessman
Marie Lesieur (1799–1890), known as Marie Lesueur, French ballet dancer