Leopoldo is a given name, the Italian, Spanish, and Portiguese form of the English, German, Dutch, Polish, and Slovene name, Leopold. Notable people with the name include:
Leopoldo Calvo-Sotelo (1926–2008), Spanish politician
Leopoldo de' Medici (1617-1675), Italian cardinal and Governor of Siena
Leopoldo López Escobar (1940–2013), Chilean geochemist
Leopoldo López Mendoza (born 1971), Venezuelan politician and economist
Leopoldo Sucre Figarella (1926–1996), Venezuelan politician and engineer
Leopoldo Galtieri (1926–2003) Argentine general and dictator from 1981 to 1982
