Leno is a surname. Notable people with the surname include:
Bernd Leno (born 1992), German footballer
Dan Leno (1860–1904), English music hall comedian
Jay Leno (born 1950), American comedian, actor, voice actor, writer, producer and television host
John Bedford Leno (1826–1894), English radical activist
Mark Leno (born 1951), United States politician