Leko is a surname. Notable people with the surname include:
Dimitrije T. Leko (1863–1914), Serbian architect
Ivan Leko (born 1978), Croatian footballer
Jerko Leko (born 1980), Croatian footballer
Josip Leko (born 1948), Croatian politician and Speaker of the Croatian Parliament
Marko Leko (1853–1932), Serbian chemist and president of the Serbian Red Cross
Peter Leko (born 1979), Hungarian chess player
Stefan Leko (born 1974), German-Croatian kickboxer