Leighton is an English surname. Notable people with the surname include:
Alexander Leighton (1587–1644), Scottish physician and pamphleteer
Alexander H. Leighton (1908-2007), sociologist and psychiatrist
Bernardo Leighton, Chilean Christian Democrat
David Keller Leighton, Sr., American Episcopalian bishop
Dorothea Leighton (1908-1989), American social psychiatrist and a founder of the field of medical anthropology
Edmund Blair Leighton (1853–1922), English painter
Edward Leighton (disambiguation), several people
Frederic Leighton, 1st Baron Leighton (1830–1896), English painter and sculptor
F. Thomson Leighton, computer scientist and co-founder of Akamai Technologies
Baron Leighton of St Mellons, UK peerage title
Jim Leighton, Scottish footballer
Kenneth Leighton, English composer
Laura Leighton (born 1968), US actor
Robert Leighton (1611–1684), Scottish prelate
Warner E. Leighton, film editor, mainly for Hanna-Barbera
Michael Leighton (born 1981), Canadian ice hockey goaltender
