Leibowitz is a Jewish surname. Notable people with the surname include:
Henoch Leibowitz (c.1918–2008), head of the Rabbinical Seminary of AmericaJacob Leibowitz, possible birth name of Jacob Frank (1726–1791), leader of a Jewish messianic movementJon Leibowitz (born 1958), former United States Federal Trade Commission chairmanJonathan Stuart Leibowitz, better known as Jon Stewart (born 1962), American political satirist, formerly of The Daily ShowMartin L. Leibowitz, financial researcher and business leaderNechama Leibowitz (1905–1997), sometimes Nehama Leibowitz, Israeli Bible scholarRené Leibowitz, (1913–1972) a French composer of Polish-Latvian originSamuel Leibowitz (1893–1978), New York trial lawyerYeshayahu Leibowitz (1903–1994), Israeli thinker and scientist