Leftwich is a surname. Notable people with the surname include:
Adrian Leftwich (1940–2013), South African anti-apartheid activist and academicBenjamin Francis Leftwich (born 1989), English singer-songwriterBrad Leftwich (born 1953), American fiddler and banjoistByron Leftwich (born 1980), American football playerDebbe Leftwich, American politicianJabez Leftwich (1765–1855), American politicianJohn W. Leftwich (1826–1870), American politicianJoseph Leftwich (1892–1983), English writer, poet, critic and translatorKeith Leftwich (1954–2003), American politicianPhil Leftwich (born 1969), American baseball playerWilliam G. Leftwich, Jr. (1931–1970), United States Marine Corps officer