Leelamine

Leelamine (dehydroabietylamine) is a diterpene amine that has weak affinity for the cannabinoid receptors CB₁ and CB₂, as well as being an inhibitor of pyruvate dehydrogenase kinase. Optically active leelamine is also used as a chiral resolving agent for carboxylic acids. Leelamine has been shown to be effective against certain cancer cells, independent from its activity on Cannabinoids or PDK1. Due to its lysosomotropic property, it accumulates inside the acidic organelles leading to distruption of intracellular cholesterol transport, autophagy and endocytosis followed by cell death.