Ledford is a surname. Notable people with the surname include:
Brandy Ledford (born 1969), American actress, model and former Penthouse Pet of the Year
Cawood Ledford (1926–2001), announcer for the University of Kentucky basketball and football teams
Dwayne Ledford (born 1976), former center in the National Football League
Frank F. Ledford, Jr. (born 1934), orthopedic surgeon and 37th Surgeon General of the United States Army 1988–1992
Homer Ledford (1927–2006), instrument maker and bluegrass musician from Kentucky who specialized in making dulcimers
John Ledford (born 1968), American entrepreneur, co-founder and former president of ADV Films
Lily May Ledford (1917–1985), American clawhammer banjo and fiddle player
Mark Ledford (1960–2004), American trumpet player, vocalist, guitarist and drummer
