Routes of
administration IV CAS Number 247207-64-3 ChemSpider 17288914 | ATC code None PubChem CID 16132255 Molar mass 2,756.234 g/mol | |
Synonyms H-Cys-Lys-Ser-Lys-Gly-Ala-Lys-Cys-Ser-Lys-Leu-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Ser-Gly-Thr-Val-Gly-Arg-Cys-NH2 | ||
Leconotide (INN) (code names CNSB004, AM336), also known as ω-conotoxin CVID, is an ω-conotoxin peptide isolated from the venom of Conus catus which is under investigation as an analgesic drug for the treatment of pain conditions.
It acts as an N-type voltage-gated calcium channel (Cav2.2) blocker, and is highly selective for this channel over the related P/Q-type voltage-gated calcium channel (Cav2.1).
Relative to ziconotide, leconotide is advantageous in that it is significantly less toxic, and for that reason can be administered intravenously as opposed to via intrathecal injection.
References
Leconotide Wikipedia(Text) CC BY-SA