Le Sueur or Lesueur is a French surname. Notable people with the surname include:
Charles Alexandre Lesueur, French naturalist/artist
Clinton LeSueur, Mississippi politician
Eustache Le Sueur, a French painter
Hubert Le Sueur, a French sculptor
Jacques-François le Sueur, French Jesuit missionary
Jean-François Le Sueur, a French composer
Jean Le Sueur, a French priest
Meridel Le Sueur, an American writer
Pierre-Charles Le Sueur, a French explorer of North America
Pierre-Étienne Lesueur, a French painter
Terry Le Sueur, a politician in Jersey
Hal LeSueur, American actor of Huguenot descent
Lucille LeSueur, real name of Joan Crawford, sister of above
