Kalpana Kalpana (Editor)

Laudexium metilsulfate

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Routes of administration
  
IV

Synonyms
  
Laudolissin

PubChem CID
  
18618

Bioavailability
  
100% (IV)

CAS Number
  
3253-60-9

Molar mass
  
1,077.35 g/mol

Laudexium metilsulfate httpsuploadwikimediaorgwikipediacommonsthu

Legal status
  
discontinued from clinical use

Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Laudexium is no longer used in clinical practice, though it was introduced clinically in the early 1950s. It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine. As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases.

The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.

References

Laudexium metilsulfate Wikipedia