Entrez 23266 | Ensembl ENSG00000117114 | |
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External IDs MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2 |
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.
References
Latrophilin 2 Wikipedia(Text) CC BY-SA