Species Human Entrez 3909 | Human Mouse Ensembl ENSG00000053747 | |
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Aliases LAMA3, BM600, E170, LAMNA, LOCS, lama3a, Laminin, alpha 3, laminin subunit alpha 3 External IDs MGI: 99909 HomoloGene: 18279 GeneCards: LAMA3 | ||
Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene.
Contents
Function
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 chain of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified.
It may be associated with Laryngoonychocutaneous syndrome.
Interactions
Laminin, alpha 3 has been shown to interact with SDC2.