Lagonegro Cathedral (Italian: Duomo di Lagonegro; Concattedrale di San Nicola di Bari) is a Roman Catholic cathedral dedicated to Saint Nicholas located in the comune of Lagonegro in Basilicata, Italy. Since 1976 it has been a co-cathedral of the Roman Catholic Diocese of Tursi-Lagonegro.
The church was built in the ninth and tenth centuries, but has been renovated many times since. The interior is very spacious and heterogenous, owing to several expansions. Treasures include a crucifix by Altobello Persio, a depiction of Mary and the saints by Giovanni Bernardino Azzolini and the main altar, which dates to the 1700s.
Legend has it that the church contains the tomb of Lisa del Giocondo, the subject of the Mona Lisa, who died at Lagonegro in 1506.