Supriya Ghosh (Editor)

Laboratory of Neuro Imaging

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Website
  
www.loni.usc.edu

Laboratory of Neuro Imaging httpsuploadwikimediaorgwikipediaenthumb4

Industry
  
Education Research Science

Headquarters
  
Los Angeles, California, USA

The Laboratory of Neuro Imaging (LONI) is a research laboratory founded within the Department of Neurology at the UCLA David Geffen School of Medicine. In September, 2013, LONI moved to Keck School of Medicine of USC. The laboratory conducts a wide variety of brain imaging studies of normal brain anatomy and function, development, aging, and disease. Historically, research at LONI has focused on design, development, validation and wide dissemination of software tools for use in understanding the relationships between brain structure and function across space, time and scale. In particular, work has been conducted toward the construction of multidimensional brain atlases seeking to promote computationally efficient representations of brain anatomy, function and physiology in a standardized 3D coordinate system. Brain imaging modalities include MRI, fMRI, Diffusion Tensor Imaging, Magnetic Resonance Spectroscopy, Positron Emission Tomography, Optical Intrinsic Signal, among other means for gathering spatially based neurophysiological signals.

Research

Examples of the brain mapping research conducted at LONI include:

  • Alzheimer's disease: Investigating structural, functional, metabolic and pathological changes triggered by Alzheimer's disease. LONI research focuses on characterizing the timecourse of pathology in the AD brain.
  • Normal brain development and neurodevelopmental disorders: LONI development efforts have focused on assessing structural brain changes by mapping anatomical growth and pruning associated with both normal and abnormal brain development during childhood and adolescence.
  • Optical Intrinsic Signal Imaging: Mapping the brain by measuring intrinsic activity-related changes in tissue reflectance.
  • Schizophrenia: Mapping heritability and effects of risk genes on structural features in the brain.
  • Atlasing of the C57BL/6J mouse brain
  • Neuronal white matter tract tracing in the mouse
  • Mathematical modeling
  • Neuroscience databasing
  • Applications of Grid computing in the neurosciences
  • References

    Laboratory of Neuro Imaging Wikipedia