La Salle or Lassalle is a surname. Notable people with the surname include:
Antoine Charles Louis de Lasalle (1775–1809), French cavalry general during the French Revolution and Napoleonic Wars
Denise LaSalle (born 1939), singer
Eriq La Salle (born 1962), actor
Ferdinand Lassalle (1825–1864), German-Jewish jurist and socialist political activist
Gadifer de la Salle (1340–1415), French soldier of Norman origin
Jean-Baptiste de La Salle (1651–1719), Patron saint of Teachers and Founder of Institute of the Brothers of the Christian Schools
Mick LaSalle (born 1959), movie critic for the San Francisco Chronicle
Nicolas de la Salle (died 1710)
René-Robert Cavelier, Sieur de La Salle (1643–1687), French explorer of North America
Joseph P. LaSalle (1916-1983), American mathematician known for the LaSalle invariance principle
