Species Human Entrez 3936 | Human Mouse Ensembl ENSG00000136167 | |
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Aliases LCP1, CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1 External IDs MGI: 104808 HomoloGene: 80174 GeneCards: LCP1 | ||
Gene music using protein sequence of lcp1 lymphocyte cytosolic protein 1 l plastin
Plastin-2 is a protein that in humans is encoded by the LCP1 gene.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.