Entrez 26524 | Ensembl ENSG00000150457 | |
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Aliases LATS2, KPM, large tumor suppressor kinase 2 External IDs MGI: 1354386 HomoloGene: 56678 GeneCards: LATS2 |
Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
References
LATS2 Wikipedia(Text) CC BY-SA