L gulonate 3 dehydrogenase

In enzymology, a L-gulonate 3-dehydrogenase (EC 1.1.1.45) is an enzyme that catalyzes the chemical reaction

L-gulonate + NAD⁺ ⇌ 3-dehydro-L-gulonate + NADH + H⁺

Thus, the two substrates of this enzyme are L-gulonate and NAD⁺, whereas its 3 products are 3-dehydro-L-gulonate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-gulonate:NAD⁺ 3-oxidoreductase. Other names in common use include L-3-aldonate dehydrogenase, L-3-aldonic dehydrogenase, L-gulonic acid dehydrogenase, L-beta-hydroxyacid dehydrogenase, L-beta-hydroxy-acid-NAD⁺-oxidoreductase, and L-3-hydroxyacid dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.