Löffler or Loeffler is a German surname. Notable people with the surname include:
Anna Seelig-Löffler (born 1944), Swiss chemistAugust Löffler (1822–1866), German painterCharles Martin Loeffler (1861–1935), German-born American composerCullen Loeffler (born 1981), American National Football League playerFrank Löffler (born 1980), German ski jumperFriedrich Löffler (1852–1915), German bacteriologistKlebs-Löffler bacillusGerold Löffler, Swiss bobsledderKarl Löffler, head of the Jewish Affairs department of the Gestapo in Cologne, Germany during in the 1930s and 1940sKen Loeffler (1902–1975), American collegiate and professional basketball coachLeopold Loeffler (1827–1898), Polish painterLouis R. Loeffler (1897–1972), American Academy Award-nominated film editorMargot Klestil-Löffler (born 1954), Austrian diplomatPete Loeffler (born 1976), guitarist and singerScot Loeffler (born 1974), American football coachTom Loeffler (born 1946), American politician from Texas