Kynurenate 7,8 dihydrodiol dehydrogenase

In enzymology, a kynurenate-7,8-dihydrodiol dehydrogenase (EC 1.3.1.18) is an enzyme that catalyzes the chemical reaction

7,8-dihydro-7,8-dihydroxykynurenate + NAD⁺ ⇌ 7,8-dihydroxykynurenate + NADH + H⁺

Thus, the two substrates of this enzyme are 7,8-dihydro-7,8-dihydroxykynurenate and NAD⁺, whereas its 3 products are 7,8-dihydroxykynurenate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase. Other names in common use include 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase, and 7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase. This enzyme participates in tryptophan metabolism.