Species Human Entrez 3786 | Human Mouse Ensembl ENSG00000184156 | |
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Aliases KCNQ3, BFNC2, EBN2, KV7.3, potassium voltage-gated channel subfamily Q member 3 External IDs OMIM: 602232 MGI: 1336181 HomoloGene: 20949 GeneCards: KCNQ3 | ||
Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.
It is associated with benign familial neonatal epilepsy.
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).
Interactions
KvLQT3 has been shown to interact with KCNQ5.