Knatchbull-Hugessen is a compound surname. Notable people with the name include:
Adrian Knatchbull-Hugessen (1891–1976), Canadian lawyer and senatorCecil Knatchbull-Hugessen, 4th Baron Brabourne (1863–1933), English cricketer and British peerEdward Knatchbull-Hugessen, 1st Baron Brabourne (1829–1893), British Liberal politicianEdward Knatchbull-Hugessen, 2nd Baron Brabourne, (1857–1909), British peer and Liberal Party politicianHerbert Knatchbull-Hugessen (1835–1922), British Conservative politicianHughe Knatchbull-Hugessen (1886–1971), British diplomatWilliam Knatchbull-Hugessen (1837–1864), English cricketerWyndham Knatchbull-Hugessen, 3rd Baron Brabourne (1885–1915), British peer and British Army officer