Klugman is a surname. Notable people with the surname include:
Adam Klugman (born 1963), media strategist and campaign consultant
Brian Klugman (born 1975), American actor
Dick Klugman (1924–2011), Austrian-born Australian politician
Jack Klugman (1922-2012), American stage, film and television actor
Jeni Klugman, female development economist
Patrick Klugman (born 1977), French attorney and politician