Klinghoffer is a German surname. Notable people with the surname include:
David Klinghoffer, author and essayist at the Discovery Institute, and proponent of intelligent design
Josh Klinghoffer (born 1979), musician and record producer from Los Angeles, California, and current guitarist for the Red Hot Chili Peppers
Leon Klinghoffer (1916–1985), disabled American who was murdered and thrown overboard in the hijacking of the cruise ship Achille Lauro in 1985
Yitzhak Klinghoffer (1905–1990), Israeli jurist and politician
