Kipnis is a surname. Notable people with the surname include:
Alexander Kipnis (1891–1978), Russian/Ukrainian/American operatic bassIgor Kipnis (1930–2002), German-born American harpsichordist and pianistJason Kipnis (born 1987), American baseball player (second baseman; Cleveland Indians)Joel Kipnis (aka JK), producer, writer, soul/R&B guitarist, and recording studio ownerJonathan Kipnis, professor of neuroscience at the University of VirginiaLaura Kipnis (born 1956), American professor of media studies at Northwestern UniversityLevin Kipnis (1894–1990), Russian/Ukrainian-born Israeli children's author and poet; winner of the Israel Prize