Killigrew is a surname of English origin. Notable people with this surname include:
Alan Killigrew (1919–2001), Australian Rules footballer and coachAnne Killigrew (1660–1685), English poetCatherine Killigrew (1618–1689)Lady Catherine Killigrew (c.1530–1583), English scholarElizabeth Killigrew, Viscountess Shannon (1622–1680), wife of Francis Boyle and mistress to Charles II of EnglandHenry Killigrew (disambiguation), several peopleSir Robert Killigrew (1580–1633), English courtier and MPThomas Killigrew (1612–1683), dramatist and theatre managerWilliam Killigrew (disambiguation), several people