Killigrew is a surname of English origin. Notable people with this surname include:
Alan Killigrew (1919–2001), Australian Rules footballer and coach
Anne Killigrew (1660–1685), English poet
Catherine Killigrew (1618–1689)
Lady Catherine Killigrew (c.1530–1583), English scholar
Elizabeth Killigrew, Viscountess Shannon (1622–1680), wife of Francis Boyle and mistress to Charles II of England
Henry Killigrew (disambiguation), several people
Sir Robert Killigrew (1580–1633), English courtier and MP
Thomas Killigrew (1612–1683), dramatist and theatre manager
William Killigrew (disambiguation), several people
