Killeen is a surname of Irish origin. Notable people with the surname include:
Caroline Killeen (born 1926), American activistDonald Killeen (1923–1972), Irish-American criminalEvans Killeen (born 1936), American baseball playerGraham Killeen (born 1980), American filmmaker and criticGretel Killeen (born 1963), Australian television personalityHenry Killeen (1872–1916), American baseball playerJ. J. Killeen (born 1981), American golferJames Jerome Killeen (1917–1978), American Roman Catholic bishopJason Killeen (born 1980), Irish basketball playerJohn Killeen (1920–2005), Irish hurlerLen Killeen (1938–2011), South African rugby league football playerLewis Killeen (born 1982), English football (soccer) playerLiam Killeen (born 1982), English professional mountain bikerMark Killeen, British actorNeil Killeen (born 1975), English cricketerOliver Killeen (born 1937), Irish bigamist and fraudsterPatrick Killeen (born 1990), Canadian ice hockey playerPeter Richard Killeen (born 1942), American psychologistRichard Killeen (born 1946), New Zealand painter, sculptor and digital artistRyan Killeen (born 1983), American football (American football) playerTimothy Killeen (1923–1993), Irish politicianTony Killeen (born 1952), Irish politician