Killeen is a surname of Irish origin. Notable people with the surname include:
Caroline Killeen (born 1926), American activist
Donald Killeen (1923–1972), Irish-American criminal
Evans Killeen (born 1936), American baseball player
Graham Killeen (born 1980), American filmmaker and critic
Gretel Killeen (born 1963), Australian television personality
Henry Killeen (1872–1916), American baseball player
J. J. Killeen (born 1981), American golfer
James Jerome Killeen (1917–1978), American Roman Catholic bishop
Jason Killeen (born 1980), Irish basketball player
John Killeen (1920–2005), Irish hurler
Len Killeen (1938–2011), South African rugby league football player
Lewis Killeen (born 1982), English football (soccer) player
Liam Killeen (born 1982), English professional mountain biker
Mark Killeen, British actor
Neil Killeen (born 1975), English cricketer
Oliver Killeen (born 1937), Irish bigamist and fraudster
Patrick Killeen (born 1990), Canadian ice hockey player
Peter Richard Killeen (born 1942), American psychologist
Richard Killeen (born 1946), New Zealand painter, sculptor and digital artist
Ryan Killeen (born 1983), American football (American football) player
Timothy Killeen (1923–1993), Irish politician
Tony Killeen (born 1952), Irish politician
