Khayat, Khayyat is an Arabic-language occupational surname, literally meaning "tailor". Notable people with the surname include:
Bill Khayat (born 1973), American football coach
David Khayat (born 1956), French oncologist
Ed Khayat (born 1935), American football player
Jana Khayat, British businesswoman
Jean Khayat (born 1942), Tunisian Olympic fencer
Mirna Khayat, Lebanese music video director
Nadir Khayat, known by the stage name RedOne, Morocco-born Swedish producer and songwriter
Robert Khayat (born 1938), American academic, Chancellor of the University of Mississippi
Elías Khayat (born 1939 in Syria, Naturalized Argentinean), Violinist, Musical Director, Director of 'Camerata Bariloche' 1980-1992 chamber orchestra
