Khalaf is both a given name and a surname. Notable people with the name include:
Given name:
Khalaf al-Bazzar (d. 844), canonical reader of the Qur'an
Khalaf I (937–1009), Amir of Sistan
Khalaf Al-Enezi (born 1952), Kuwaiti politician
Khalaf Al Salamah (born 1979), Kuwaiti footballer
Khalaf al-Ulayyan, Iraqi politician
Khalaf Khalafov (born 1959), Azerbaijani politician
Khalaf Masa'deh (died 2015), Jordanian lawyer and politician
Khalaf M Alanazi, Faculty member at Northern Border University, Saudi Arabia
Surname:
Abbas Khalaf, Iraqi translator
Abdulhadi Khalaf (born 1945), Bahrani political activist and academic
Abdulhadi Khalaf (footballer) (born 1986), Syrian footballer
Ahmad Ibrahim Khalaf (born 1992), Iraqi footballer
Aline Khalaf (born 1974), Lebanese singer
Karim Khalaf (1935–1985), Palestinian politician
Khaled Khalaf (born 1983), Kuwaiti footballer
Mohamed Khalaf, Egyptian footballer
Rima Khalaf (born 1953), Jordanian UN official
Salah Khalaf (1933–1991), Palestinian PLO official
Samir Khalaf (born 1933), Lebanese sociologist
Ubay ibn Khalaf, contemporary of Muhammad
Umayyah ibn Khalaf, contemporary of Muhammad