Ketchum is a surname. Notable people with the surname include:
Brandon Ketchum (born 1976), speculative fiction writer
Daniel Ketchum (born 1981), former American swimmer
Gerald Ketchum (1908–1992), commanded the icebreaker USS Burton Island (AG-88)
Gus Ketchum (1897–1980), American Major League Baseball pitcher
Hal Ketchum (born 1953), country music singer
Jack Ketchum (born 1946), horror writer
Jesse Ketchum (1782–1867), tanner and political figure in Upper Canada
Menis E. Ketchum, Chief Justice of the Supreme Court of Appeals of West Virginia
Morris Ketchum (1796–1880), American banker and financier of the 19th century
Richard Ketchum (1773–1845), political figure in New Brunswick
Robert Glenn Ketchum (born 1947), landscape and nature photographer
Rufus Lloyd Ketchum, a Sergeant in the United States Army during the Korean War
Tom Ketchum (1863–1901), a.k.a. "Black Jack" Ketchum, U.S. Western outlaw
Wesley Harrington Ketchum (1878-1968), medical doctor, introduced Edgar Cayce to the national medical community in a 1910 presentation to the American Association for Clinical Research
William Ketchum, 14th Mayor of the City of Buffalo, New York
William F. Ketchum, inventor of the Ketchum Hand Grenade
William M. Ketchum (1921–1978), U.S. Representative
William Scott Ketchum (1813–1871), U. S. Army officer before and during the American Civil War
Fictional characters:
Ash Ketchum, a Pokémon Trainer
Delia Ketchum, his mother
Kevin Ketchum, an OZ prisoner