Keeton is a surname. Notable people with the surname include:
Bob Keeton (1918–1996), English footballerCheryl Keeton (1949–1986), American lawyerChuckie Keeton (born 1993), American football playerDurwood Keeton (born 1952), American football playerFrederick Keeton (1855–1911), English cricketerHaydn Keeton (1847–1921), American football playerJohn Keeton (born 1972), British boxerKathy Keeton (1309–1997), American magazine publisherRickey Keeton (born 1957), American baseball playerRobert Keeton (1919–2007), American lawyerRuth U. Keeton (1919–1997), American politicianW. Page Keeton (1909–1999), American attorneyWalter Keeton (1905–1980), English cricketerWilliam Keeton (1933–1980), American zoologist