Keefe is both a surname and a masculine given name. Notable people with the name include:
Surname:
Adam Keefe (basketball) (born 1970), American basketball player
Adam Keefe (ice hockey) (born 1984), Canadian ice hockey player
Anne Keefe, American theatre director
Bobby Keefe (1882–1964), American baseball player
Brian Keefe, American basketball coach
Daniel Keefe (1852–1929), American labor leader
Dave Keefe (1897–1978), American baseball player
David Keefe (born 1957), English footballer
Denis Keefe (born 1958), British ambassador to Serbia
Dylan Keefe (born 1970), American musician
Emmett Keefe (1893–1965), American football player
Frank Bateman Keefe (1887–1952), American politician
George Keefe (1867–1935), American baseball player
James Keefe (18th century), Irish Roman Catholic bishop
Jim Keefe (born 1965), American comic strip caroonist
John Keefe (1867–1937), American baseball player
John Keefe (actor) (born 1979), American actor
Michael Edwin Keefe (1844–1933), Canadian politician
Mike Keefe (born 1946), American editorial cartoonist
P. J. Keefe, American football coach
Peter Keefe (1952–2010), American television producer
Rob Keefe (born 1980), American Arena Football League player and coach
Sheldon Keefe (born 1980), Canadian ice hockey player
Tim Keefe (1857–1933), American baseball player
William John Keefe (1873–1955), American judge
Zena Keefe (1896–1977), American actress
Given name:
Keefe Brasselle (1923–1981), American actor, television producer and writer
Keefe Cato (born 1957), American baseball player
