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Kalisz Region (Polish: Kaliskie) is a historical and ethnographical area of Poland, located in central Poland mainly in the Greater Poland Lakes Area and South Greater Poland Plain. It forms the eastern part of Greater Poland proper.
Kalisz Region encompasses the area of the former Kalisz Voivodeship, south of Lake Gopło as well as Wieluń Land. In the north it borders Kuyavia, in the south it borders Lower Silesia, in the West it borders Poznań Region and in the west it reaches the Warta River.
The largest city of the region is Kalisz, other large towns include: Konin, Ostrów Wielkopolski, Turek, Jarocin, Wieluń, Koło, Krotoszyn, Września, Kępno, Środa Wielkopolska, Pleszew, Ostrzeszów and Zagórów.
Kalisz Region is inhabited by an ethnographical group called Kaliszanie.