Kaine is a surname. Notable people with the surname include:
Bill Kaine (1900–1968), English professional footballerCarmel Kaine (1937–2013), Australian classical violinistJaiden Kaine, Cuban-American actorJohn Charles Kaine (1854–1923), Quebec politicianLaurie Kaine (born 1952), Australian rules footballerLes Kaine (1936–2012), Australian rules footballerObregon Kaine, main character in the comic book series NegationTim Kaine (born 1958), American politician and Democratic Party Vice Presidential nomineeTrevor Kaine (1928–2008), Australian politicianWhitney Kaine (born 1956), American model