Kaine is a surname. Notable people with the surname include:
Bill Kaine (1900–1968), English professional footballer
Carmel Kaine (1937–2013), Australian classical violinist
Jaiden Kaine, Cuban-American actor
John Charles Kaine (1854–1923), Quebec politician
Laurie Kaine (born 1952), Australian rules footballer
Les Kaine (1936–2012), Australian rules footballer
Obregon Kaine, main character in the comic book series Negation
Tim Kaine (born 1958), American politician and Democratic Party Vice Presidential nominee
Trevor Kaine (1928–2008), Australian politician
Whitney Kaine (born 1956), American model
